Table 1.
General characteristic of the included studies
| Author | Country | No. of patients (PRP vs HA) | Age (years, PRP vs HA) | Sex (male, PRP vs HA) | BMI (PRP vs HA) | Radiographic classification (PRP vs HA) | Follow-up (m) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | I | II | III | IV | |||||||
| Ahmad 2018 [22] | Egypt | 45/44 | 56.2/56.8 | 14/14 | NS | 0/0 | 8/7 | 17/19 | 20/18 | 0/0 | 6 |
| Buendia-Lopez 2018 [23] | Spain | 33/32 | 56.2/56.6 | 16/15 | 24.9/24.9 | 0/0 | 18/18 | 15/14 | 0/0 | 0/0 | 12 |
| Cerza 2012 [24] | Italy | 60/60 | 66.5/66.2 | 25/28 | NS | 0/0 | 21/25 | 24/22 | 15/13 | 0/0 | 6 |
| Cole 2017 [20] | USA | 49/50 | 55.9/56.8 | 28/20 | 27.4/29 | 0/0 | 3/0 | 26/27 | 20/22 | 0/0 | 12 |
| Di Martino 2019 [25] | Italy | 85/82 | 52.7/57.5 | 53/47 | 27.2/26.8 | NS | 60 | ||||
| Duymus 2017 [26] | Turkey | 33/34 | 60.4/60.3 | 1/1 | 27.6/28.4 | 0/0 | 0/0 | 22/24 | 21/10 | 11/0 | 12 |
| Filardo 2015 [19] | Italy | 94/89 | 53.3/57.6 | 60/52 | 26.6/26.9 | NS | NS | NS | NS | NS | 12 |
| Gormeli 2017 [27] | Turkey | 39/39 | 53.7/53.5 | 16/17 | 28.7/29.7 | 0/0 | 26/30 | 13/14 | 6 | ||
| Huang 2019 [28] | China | 40/40 | 54.5/54.8 | 25/19 | 25.2/24.5 | 0/0 | 40/40 | 0/0 | 0/0 | 12 | |
| Li 2011 [29] | China | 15/15 | 57.6/58.2 | 6/7 | 24.3/21.0 | 0/0 | 6/6 | 2/3 | 4/3 | 3/3 | 6 |
| Lin 2019 [17] | China | 31/29 | 61.2/62.5 | 9/10 | 24.0/26.3 | 5/6# | 16/14# | 10/9# | 12 | ||
| Louis 2018 [30] | France | 24/24 | 53.2/48.5 | 14/11 | 25.6/27.0 | 0/0 | 0/0 | 24/24 | 6 | ||
| Montanez-Heredia 2016 [31] | Spain | 27/26 | 66.3/61.5 | 12/9 | 29.0/30.4 | 0/0 | 5/2 | 10/9 | 12/15 | 0/0 | 6 |
| Paterson 2016 [32] | Australia | 11/10 | 49.9/52.7 | 8/7 | 27.9/28.9 | 0/0 | 0/0 | 11/10 | 0/0 | 3 | |
| Raeissadat 2015 [33] | Iran | 77/62 | 56.9/61.1 | 8/15 | 28.2/27.0 | 0/0 | 5/0 | 34/29 | 29/23 | 9/10 | 12 |
| Sanchez 2012 [34] | Spain | 89/87 | 60.5/58.9 | 43/42 | 27.9/28.2 | 45/43# | 32/33# | 12/11# | 6 | ||
| Su 2018 [35] | China | 25/30 | 54.2/53.1 | 11/12 | 28.2/28.7 | 0/0 | 0/0 | 16/13 | 11/12 | 0/0 | 6 |
| Vaquerizo 2013 [36] | Spain | 48/48 | 62.4/64.8 | 16/22 | 30.7/31.0 | NS | NS | 12 | |||
| Yu 2018 [37] | China | 104/88 | 46.2/51.5 | 50/48 | NS | NS | NS | 12 | |||
| Tavassoli 2019 [38] | Iran | 28/27 | 63.2/66.0 | 5/8 | 28.4/28.9 | 21/22 | 35/32 | 3 | |||
NS not stated, PRP platelet-rich plasma, HA hyaluronic acid
# Ahlbäck grade, and the rest were K–L grades