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. 2020 Sep 11;21:236. doi: 10.1186/s13059-020-02125-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — An example of a known breast cancer susceptibility locus being associated with multi-omics traits. At a posterior probability threshold of 80%, Primo identified SNP rs2992756 as being associated with all four omics traits for the gene KLHDC7A. Here shows the − log10(P) values by position on chromosome 1 in the region of the gene KLHDC7A for all SNPs including the breast cancer susceptibility locus (rs2992756, red dot) in GWAS (top panel) and eQTL, meQTL, and pQTL analyses in tumor tissue (the next three panels, respectively) and eQTL analysis in normal tissue (bottom panel) for the gene and protein KLHDC7A and CpG site cg05040210