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. 2020 Sep 11;21:236. doi: 10.1186/s13059-020-02125-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Enrichment of CpG targets of breast cancer susceptibility loci among genomic features. a Distribution with relation to islands of CpG targets of Primo-identified multi-omics QTLs and meQTL-only susceptibility loci compared with distribution of all CpGs on 450k array. Numbers represent counts of CpGs in each relationship to islands. b Fold enrichment or depletion of genomic features among CpG targets of multi-omics QTL (cyan) and meQTL-only (pink) susceptibility loci. Feature counts out of total CpG targets are displayed within each bar. X-axis displayed on log scale. P values were obtained by bootstrapping samples of CpGs from the full 450k array [* P<0.01, ** P<10⁻³]