Table 3.
Cardiovascular and respiratory effects of i.t. injected PK23.
| Factor | PK23 |
NaCl |
||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 0 min | MAX | 10 min | Baseline | 0 min | MAX | 10 min | |
| VE, (mL/min) | 121 ± 12 | 118 ± 10 | 122 ± 13 | 113 ± 14 | 120 ± 8 | 119 ± 9 | 124 ± 5 | 120 ± 7 |
| HR (beat/min) | 436 ± 24 | 439 ± 24 | 435 ± 31 | 418 ± 32 | 404 ± 33 | 403 ± 32 | 415 ± 33 | 411 ± 36 |
| MAP (mm Hg) | 83 ± 4 | 76 ± 5 | 97 ± 8 | 87 ± 7 | 83 ± 5 | 83 ± 6 | 87 ± 6 | 84 ± 7 |
VE, minute ventilation; HR, heart rate; MAP, mean arterial blood pressure; Baseline, before injection, 0 min, early phase after injection, MAX, maximum value selected between 1 and 5 min after injection; n = 5 for PK23 and n = 4 for NaCl treated rats.