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. 2019 Dec 27;10(8):1492–1510. doi: 10.1016/j.apsb.2019.12.013

Figure 1.

Figure 1

The mRNA and protein expression levels of MDM2 and CDK4 in various type of cancers. (A) Transcripts per million reads of MDM2 in every type of cancers retrieved from GEPIA database. (B) The differential expression and mutation status of MDM2, TP53 and CDKs in glioblastoma cohort retrieved from cBioportal and TCGA database. (C) The boxplot of MDM2 and CDK4 expression in glioblastoma cohort retrieved from TCGA database (∗P < 0.05). (D) The expression correlation of MDM2 and CDK4 in both tumor and normal samples from TCGA and GTEx database (left panel) and only tumor samples in TCGA database (right panel). (E) The protein expression levels of MDM2 and CDK4 determined by IHC in glioblastoma and normal cerebral cortex tissues, retrieved from ProteinAtlas database, scale bar: 200 μm.