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. 2019 Dec 27;10(8):1492–1510. doi: 10.1016/j.apsb.2019.12.013

Figure 2.

Figure 2

(A) Typical model of how the C3-spirooxindole framework interacts with MDM2. (B) Naphthalene derivatives are an effective framework for CDK4 inhibitors. (C) The combination of C3-spirooxindole and tetrahydronaphthalene (THN) may generate a novel dual-inhibitor of MDM2 and CDK4.