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Overview of anti-NSCLC effect triggered by DOX-OMV. In vitro, DOX encapsulated in OMVs was efficiently delivered into A549 cells, thus resulted in intensive cytotoxic effects and cell apoptosis. In vivo, OMVs not only functioned as drug delivery carriers but also induced the recruitment of macrophages in tumor microenvironment which might synergize with their cargo DOX.
