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VEGFR2/FGFR1/PDGFRβ inhibition of the typical compounds B1–B3 obtained by R2 group optimization.
| Compd. | Structure or R2 | IC50 (nmol/L) |
||
|---|---|---|---|---|
| VEGFR2 | FGFR1 | PDGFRβ | ||
| Lead compd. | CH3 | 9.4 | 188.0 | 143.0 |
| B1 |  |
335.2 | 9032.0 | 388.9 |
| B2 |  |
26.7 | 216.4 | 56.9 |
| B3 |  |
226.8 | 777.1 | 409.8 |
