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. 2020 Sep 11;20:873. doi: 10.1186/s12885-020-07376-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CTC mobilization with different chemotherapeutic regimens. a Box and whisker charts show the fold change in CTC counts after 1 and 2 cycles of treatment with: A combination of Fluorouracil, Oxaliplatin and Irinotecan, or alkylating agent-, plant alkaloids-, antimetabolite- and inhibitor-based chemotherapy. Lines connect individual patients (median ± range, N = 72 from 30 Met-pa). The changes in the median CTC level over the course of each treatment was tested for significance with a paired Wilcoxon test. b Box and whisker plots represent the fold change in CTC counts post-chemotherapy in patients showing continuous progression of cancer. Lines connect individual patients (median ± range, N = 9 from 3 Met-pa). The change in median CTC level post-treatment was not significant using a paired Wilcoxon test (0.500 < P > 0.999)