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. 2020 Sep 11;20:873. doi: 10.1186/s12885-020-07376-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Minimal reduction of CTC viability by chemotherapy and soluble TRAIL. a Bar graphs display the viable CTC percentage in treated samples with PBS and chemotherapeutic agents (Docetaxel-DXT, 5-Fluorouracil-5-FU, Oxaliplatin-OXA, Paclitaxel-PTX) in Met-pa (mean ± SD, N = 24 from 10 patients at different time points of chemotherapy treatment). Significant reduction in (*P = 0.0317) in CTC viability due to the chemotherapy was determined using a paired t test. b Bar graphs represent the CTC viability percentage in samples treated with PBS and soluble TRAIL (mean ± SD, N = 12, from 6 patients). Significant reduction in CTC viability percentage (**P = 0.0048) by soluble TRAIL was calculated using a paired t test. c Immunofluorescence photomicrographs of viable cells obtained from breast, prostate and colorectal cancer patients after ex vivo treatment with chemotherapies, including docetaxel, paclitaxel, and soluble TRAIL (CD45 is red, cytokeratin is green and DAPI is blue). Scale bar is 40 μm