Table 2.
KEGG pathways directly or indirectly involved in hepatocyte differentiation
| Pathway | Count | P value | Fold enrichment |
|---|---|---|---|
| Pluripotency, differentiation, and development | |||
| Signaling pathways regulating pluripotency of stem cells | 27 | 0.0572 | 1.42 |
| Wnt signaling pathway | 32 | 0.0027 | 1.71 |
| TGF-beta signaling pathway | 22 | 0.0034 | 1.93 |
| Cellular community | |||
| Focal adhesion | 50 | 0.0000 | 1.79 |
| ECM-receptor interaction | 28 | 0.0000 | 2.37 |
| Adherens junction | 18 | 0.0124 | 1.87 |
| Tight junction | 21 | 0.0112 | 1.78 |
| Gap junction | 18 | 0.0815 | 1.50 |
| Regulation of actin cytoskeleton | 37 | 0.0795 | 1.30 |
| PI3K-Akt signaling pathway | 67 | 0.0019 | 1.43 |
| Hippo signaling pathway | 35 | 0.0017 | 1.71 |
| Hepatocyte function | |||
| Bile secretion | 17 | 0.0203 | 1.81 |
| Insulin signaling pathway | 26 | 0.0778 | 1.39 |
| PPAR signaling pathway | 16 | 0.0324 | 1.76 |