Table 3.
List of 26 categories of upstream regulators identified for DEGs
| # | Predicted activation | Predicted inhibition | |
|---|---|---|---|
| Biologic drug | 33 | 1 | 5 |
| Chemical - endogenous | 230 | 11 | 17 |
| Chemical - kinase inhibitor | 43 | 0 | 10 |
| Chemical - protease inhibitor | 14 | 2 | 0 |
| Chemical - other | 6 | 0 | 0 |
| Chemical drug | 423 | 27 | 80 |
| Chemical reagent | 104 | 7 | 15 |
| Chemical toxicant | 108 | 18 | 8 |
| Complex | 70 | 13 | 9 |
| Cytokine | 56 | 11 | 6 |
| Enzyme | 258 | 28 | 25 |
| Fusion gene/product | 16 | 3 | 3 |
| G-protein coupled receptor | 41 | 7 | 1 |
| Group | 113 | 16 | 11 |
| Growth factor | 64 | 29 | 2 |
| Ion channel | 10 | 1 | 1 |
| Kinase | 150 | 28 | 8 |
| Ligand-dependent nuclear receptor | 35 | 4 | 5 |
| MicroRNA | 110 | 0 | 47 |
| Peptidase | 50 | 10 | 1 |
| Phosphatase | 23 | 2 | 0 |
| Transcription regulator | 480 | 78 | 50 |
| Translation regulator | 16 | 3 | 0 |
| Transmembrane receptor | 56 | 7 | 3 |
| Transporter | 63 | 5 | 5 |
| Other | 386 | 53 | 26 |
| Total | 2958 | 364 | 338 |