Table 4.
List of 52 upstream transcription factors within the DEGs
| Transcription regulator | Fold change | Predicted activation | Activation z-score | P value of overlap | # Target molecules in dataset |
|---|---|---|---|---|---|
| HNF4A | − 3.385 | Inhibited | − 5.745 | 2.70E−27 | 750 |
| TP53 | − 2.129 | Activated | 3.271 | 7.29E−48 | 726 |
| MYC | − 2.262 | Activated | 5.269 | 6.14E−33 | 486 |
| CTNNB1 | 5.332 | Activated | 4.818 | 3.26E−28 | 384 |
| SMARCA4 | 2.68 | Activated | 2.141 | 1.39E−18 | 256 |
| STAT3 | − 3.854 | Activated | 2.077 | 6.50E−14 | 236 |
| HNF1A | − 2.214 | Inhibited | − 4.778 | 5.03E−20 | 213 |
| HIF1A | 6.735 | Activated | 4.443 | 1.26E−13 | 176 |
| PPARGC1A | 47.619 | Inhibited | − 5.494 | 1.69E−19 | 168 |
| POU5F1 | − 4.011 | Activated | 3.538 | 1.80E−06 | 123 |
| YAP1 | 4.979 | Activated | 3.935 | 1.89E−11 | 117 |
| SMAD3 | 2.214 | Activated | 3.208 | 5.88E−11 | 116 |
| KLF3 | − 2.047 | Inhibited | − 2.844 | 4.20E−05 | 115 |
| NOTCH1 | 2.518 | Activated | 2.574 | 9.65E−06 | 98 |
| MITF | 2.081 | Activated | 3.233 | 3.52E−05 | 87 |
| ETS1 | 19.431 | Activated | 2.415 | 1.34E−05 | 84 |
| TWIST1 | 6.797 | Activated | 2.226 | 1.63E−10 | 79 |
| SOX4 | 50.964 | Activated | 3.166 | 2.79E−06 | 75 |
| SMAD7 | 4.099 | Inhibited | − 2.615 | 1.64E−10 | 74 |
| MYB | − 2.015 | Activated | 3.237 | 2.10E−05 | 69 |
| EGR1 | − 6.18 | Activated | 2.985 | 1.19E−03 | 66 |
| LEF1 | 11.741 | Activated | 2.657 | 1.37E−05 | 61 |
| CBX5 | 3.806 | Inhibited | − 3.141 | 3.15E−09 | 59 |
| RBPJ | 2.248 | Inhibited | − 2.082 | 1.14E−04 | 59 |
| NFAT5 | 2.319 | Activated | 2.291 | 2.97E−07 | 48 |
| MLXIPL | − 6.246 | Activated | 4.068 | 4.44E−04 | 47 |
| TEAD1 | 2.73 | Activated | 3.536 | 3.29E−08 | 39 |
| IRF7 | − 4.895 | Inhibited | − 3.731 | 1.00E+00 | 39 |
| MTPN | 2.647 | Activated | 3.39 | 1.23E−04 | 36 |
| KLF5 | 15.642 | Activated | 3.404 | 4.43E−06 | 31 |
| HAND2 | 14.283 | Activated | 2.342 | 2.90E−04 | 30 |
| PLAG1 | 18.451 | Activated | 2.835 | 2.52E−04 | 26 |
| KLF15 | 12.019 | Inhibited | − 3.222 | 4.42E−04 | 23 |
| E2F6 | 2.874 | Inhibited | − 2.32 | 3.98E−02 | 22 |
| NFATC4 | 6.717 | Activated | 2.088 | 7.85E−03 | 15 |
| EED | 4.823 | Inhibited | − 2.121 | 1.59E−01 | 14 |
| ETV1 | − 3.182 | Activated | 2.085 | 4.82E−04 | 14 |
| CREB3L3 | − 9.434 | Inhibited | − 2.977 | 4.82E−04 | 14 |
| SMARCD3 | 3.952 | Activated | 2.891 | 1.69E−04 | 13 |
| MTDH | − 2.891 | Activated | 2.026 | 1.06E−01 | 13 |
| BTG2 | 7.736 | Inhibited | − 2.109 | 2.82E−02 | 11 |
| NFIX | − 5.255 | Inhibited | − 2.159 | 9.42E−03 | 11 |
| CREBZF | 2.133 | Activated | 3.105 | 8.44E−03 | 10 |
| STAT2 | − 2.78 | Inhibited | − 2.38 | 1.00E+00 | 10 |
| GLIS2 | 10.34 | Inhibited | − 2.333 | 1.85E−02 | 9 |
| PKNOX1 | 3.15 | Activated | 2.408 | 3.92E−02 | 9 |
| NLRC5 | − 6.873 | Inhibited | − 2.053 | 2.50E−01 | 7 |
| HIF3A | 10.89 | Inhibited | − 2.415 | 7.79E−02 | 6 |
| JARID2 | 5.327 | Inhibited | − 2.176 | 7.79E−02 | 6 |
| SERTAD2 | 3.181 | Activated | 2.387 | 1.45E−01 | 6 |
| ZFPM2 | 5.634 | Activated | 2.236 | 3.64E−01 | 5 |
| TRIM25 | − 2.353 | Inhibited | − 2.195 | 1.12E−01 | 5 |