Table 1.
Characteristics of patients according to the emphysema score on CT (defined as a CT-based emphysema score of ≥3 of total 24)
| Characteristic | Low (< 3) emphysema score (N = 312) | High (≥3) emphysema score (N = 145) | P value |
|---|---|---|---|
| Age | 64.96 ± 9.07 | 69.86 ± 8.14 | < 0.001 |
| Male | 167 (53.5) | 126 (86.9) | < 0.001 |
| ECOG PS | 0.009 | ||
| 0–1 | 309 (99.0) | 138 (95.2) | |
| ≥ 2 | 3 (1.0) | 7 (4.8) | |
| Smoking status | < 0.001 | ||
| Never | 146 (46.8) | 18 (12.4) | |
| Ever | 166 (53.2) | 127 (87.6) | |
| Pathologic staging | 0.001 | ||
| I | 203 (66.3) | 78 (54.5) | |
| II + III | 103 (33.7) | 65 (55.5) | |
| Differentiation | 0.002 | ||
| Well + moderate | 279 (89.4) | 114 (78.6) | |
| Poorly | 33 (10.6) | 31 (21.4) | |
| Driver oncogene | |||
| EGFR mutation | 69(30.3) | 29 (29.0) | 0.818 |
| ALK translocation | 8 (72.7) | 3 (27.3) | 0.760 |
| COPD | 71 (22.8) | 89 (61.4) | < 0.001 |
| FEV1/FVC | 0.74 ± 0.09 | 0.65 ± 0.12 | < 0.001 |
| FEV1, % pred | 96.36 ± 20.38 | 86.67 ± 21.41 | < 0.001 |
| Low DLCO (< 80) | 91 (30.2) | 69 (50.0) | < 0.001 |
| DLCO | 90.16 ± 19.04 | 79.67 ± 19.58 | < 0.001 |
| Pleural invasion | 77 (25.2) | 45 (31.7) | 0.149 |
| Lymphatic invasion | 94 (30.4) | 47 (32.6) | 0.635 |
| Vascular invasion | 47 (15.2) | 28 (19.4) | 0.259 |
| Extent of lung resection | 0.405 | ||
| Sublobar resection | 35 (11.2) | 20 (13.8) | |
| Lobectomy | 267 (85.6) | 123 (84.8) | |
| Pneumonectomy | 10 (3.2) | 2 (1.4) | |
Data are presented as mean ± standard deviation or number (%)
Abbreviations: EGFR epidermal growth factor receptor, ALK anaplastic lymphoma kinase, COPD chronic obstructive pulmonary disease, CT computed tomography, DLCO diffusing capacity of lung for carbon monoxide, ECOG PS Eastern Cooperative Oncology Group (ECOG) Performance Status, FEV1 Forced expiratory volume in 1 second, FVC forced vital capacity, pred predictive value