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. 2020 Sep 11;21:232. doi: 10.1186/s13059-020-02026-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Comparison of PTWAS p values for the height data from GIANT consortium and UK Biobank. Each data point represents a single gene whose PTWAS p values are computed from GIANT and UK Biobank data, respectively. There is a strong linear trend for highly significant p values (overall Spearman’s correlation =0.50,p<2.2×10⁻¹⁶). However, UK Biobank data, which have a larger sample size, show consistently higher significance