Table 2.

Overview outcome measurements

	Baseline assessment	Additional study appointment 1	PR programme	Post-PR assessment	Additional study appointment 2
Patient characteristics
Demographics, including age, gender, marital status	X
Medical history: Charlson Comorbidity Index	X
COPD history: number of exacerbations and hospital admissions	X
Smoking history and behaviour	X
Current medication	X
Use of long-term oxygen therapy	X
Safety reporting
Exacerbations			X
Hospitalisations			X
Side effects			X
Exercise capacity and exercise tolerance
Cardiopulmonary exercise test	X
Constant work rate cycle test	X			X
Incremental shuttle walk test	X*
Endurance shuttle walk test	X*			X*
6 min walk test	X†			X†
Body composition
Body mass index	X			X
Bioelectrical impedance analysis	X*			X*
Dual-energy X-ray absorptiometry scan	X†			X†
Muscle function
Quadriceps muscle strength (computerised dynamometer)	X			X
Quadriceps muscle endurance (computerised dynamometer)	X			X
One-repetition maximum	X			X
Muscle characteristics (muscle biopsy)
Components of carnosine metabolism		X			X
Muscle inflammation		X			X
Muscle oxidative stress		X			X
Pulmonary function
Spirometry/flow volume	X			X
Whole-body plethysmography	X
Diffusion capacity	X
Maximal inspiratory and expiratory pressure	X			X
Arterial blood gases, including PaO2 and PaCO2	X
Systemic factors
Systemic components of carnosine metabolism		X			X
Systemic markers of oxidative stress		X			X
Systemic markers of inflammation		X			X
Physical activity
MoveMonitor/Actigraph measurement	X			X
Questionnaires
Dyspnoea: Modified Medical Research Council	X			X
Health-related quality of life: COPD Assessment Test	X			X
Mood status: Hospital Anxiety and Depression scale	X			X
Fatigue: Checklist Individual Strength (CIS-Fatigue)	X			X
Evaluation muscle biopsy: feedback form		X			X
Canadian Occupational Performance Measurement (COPM)	X†			X†
Functional mobility
Short Physical Performance Battery	X†			X†
Cognitive function
Modified Wisconsin Card Sorting Test		X			X
Stroop Colour-Word Test\		X			X
Lung inflammation and oxidative stress
Volatile organic compounds measurement		X†			X†
Fractional exhaled nitric oxide measurement		X†			X†
Compliance
Patient diary					X
Counting remaining tablets					X

*Exclusively performed in BASE-TRAIN trial.

†Exclusively performed in BASE-ELECTRIC trial.