Figure 1.

Effect of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH) (1.5 mg/kg, subcutaneous) on arterial distension of isoflurane-anaesthetised mice. (a) Schematic depiction of the major carotid branches of the mouse with area of neck-arterial pulse oximetry indicated. Infrared (IR) light from a light emitting diode (LED) is picked up by an IR light detector after passing the perfused tissue. Recordings at (b) physiological and (c) elevated pad temperatures. Mean ± SEM (fold change of baseline, μm); n = 8–14 per group. Repeated measures analysis of variance (ANOVA) comparison to saline, ^*p ⩽ 0.05 and ^**p ⩽ 0.01. (d) Temperature-dependency of 25CN-NBOH’s effect on pulse distension, depicted in 1 Hz resolution. Vertical dotted lines in (b–d) indicate time of drug injection.