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. 2020 Feb 12;34(7):786–794. doi: 10.1177/0269881120903465

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Effect of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH) (1.5 mg/kg, subcutaneous) on the heart rate of isoflurane-anaesthetised mice at (a) physiological and (b) elevated pad temperatures. Mean ± SEM (fold change of baseline bpm); n = 8–14 per group. Repeated measures analysis of variance (ANOVA) comparison to saline, ^*p ⩽ 0.05 and ^**p ⩽ 0.01. (c) Temperature-dependency of 25CN-NBOH’s effect on heart rate, depicted in 1 Hz resolution. Vertical dotted lines indicate time of drug injection.