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Effect of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH) (1.5 mg/kg, subcutaneous) on core body temperature of isoflurane-anaesthetised mice at (a) physiological and (b) elevated pad temperatures. Mean ± SEM (fold change of baseline °C); n = 6–9 per group. Repeated measures analysis of variance (ANOVA), post-hoc comparison to saline, *p ⩽ 0.05. Vertical dotted lines indicate time of drug injection.
