Table 2.
Effect of 25CN-NBOH (1.5 mg/kg, s.c.) on autonomic functioning of isoflurane-anaesthetised mice at the 41°C pad temperature. Mean (SEM) absolute values of 20-minute baseline versus 20-minute post-injection period. N = 6–14 per group.
| 41°C | Saline |
NBOH |
||
|---|---|---|---|---|
| Baseline | Post-injection | Baseline | Post-injection | |
| Pulse distention (μm) | 484 (37) | 468 (35) | 462 (30) | 517 (30) |
|
Heart rate
(bpm) |
466 (16) | 509 (16) | 474 (18) | 523 (15) |
| Respiration rate (brpm) | 81 (7) | 70 (7) | 84 (10) | 67 (8) |
| Oxygenation (%) | 99 (0.06) | 99 (0.06) | 99 (0.07) | 99 (0.07) |
| Temperature (°C) | 37 (0.2) | 37 (0.2) | 37 (0.2) | 38 (0.3) |
25CN-NBOH: N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine; bpm: beats per minute; brpm: breaths per minute.