Table 4.
Hazard ratios of 9 biological pathway-related CpG sites after adjustment for confounders.
| CpG | Annotated genes | CpG location relative to gene | Relation to CpG island | HR | HR 95% CI | Raw P value | FDR-adjusted P value |
|---|---|---|---|---|---|---|---|
| cg00118365 | PCDHGA4; PCDHGB5; PCDHGA6 | Body; 1stExon; Body | Island | 0.86 | 0.80-0.93 | .0002 | .0007 |
| cg02539518 | IL1RN | Island | 0.72 | 0.56-0.93 | .0112 | .0126 | |
| cg07754138 | CELSR1 | Island | 0.49 | 0.29-0.80 | .0046 | .0060 | |
| cg11408933 | PCDH1 | 1.54 | 1.23-1.93 | .0002 | .0007 | ||
| cg18608017 | CDH23 | 5′UTR | S_Shore | 1.23 | 1.10-1.38 | .0002 | .0007 |
| cg19547547 | PCDHA1 | 1stExon | Island | 0.84 | 0.76-0.94 | .0017 | .0030 |
| cg21752383 | PCDHGA4; PCDHGA2; PCDHGB2 | Body; Body; 1stExon | N_Shore | 0.92 | 0.88-0.97 | .0014 | .0030 |
| cg24918705 | PCDHB4 | TSS1500 | N_Shore | 0.81 | 0.70-0.93 | .0036 | .0054 |
| cg25024993 | PCDHA7; PCDHA6; PCDHA11 | Body; Body; 1stExon | N_Shore | 0.93 | 0.87-0.99 | .0165 | .0165 |
Abbreviations: CI, confidence interval; CpG, cytosine-phosphate-guanine; HR, hazard ratio; FDR, false discovery rate.