Figure 1.

Intestinal mucosal expression of the receptor for advanced glycation end-products (RAGE). Fluorescence microscopy image of a colonic mucosal biopsy obtained from a dog diagnosed with moderate diffuse lymphoplasmacytic and eosinophilic chronic colitis. The image shows multifocal positive immunostaining (pink fluorescence; arrows) for RAGE that is located predominantly in the colonic epithelium. Bar = 50 μm. Inset: representative negative control (primary antibody omitted) confirming absence of nonspecific staining. Arrows indicate artificial autofluorescence caused by erythrocytes. Bar = 50 μm.