Table 2.
Correlation between serum soluble RAGE (receptor for advanced glycation end-products) and histologic lesions in dogs with chronic inflammatory enteropathy (n = 102) included in the study.
| Parameter correlated with serum sRAGE concentrations | Spearman ρ | p value | pcorr value |
|---|---|---|---|
| Histologic lesions (composite score) | −0.15 | 0.136 | 0.136 |
| Morphologic criteria (composite score) | −0.13 | 0.198 | 0.396 |
| Inflammatory criteria (composite score) | −0.09 | 0.357 | 0.714 |
| Stomach | |||
| Morphologic criteria | 0.01 | 0.973 | NS |
| Fundus | |||
| Surface epithelial injury | 0.04 | 0.721 | NS |
| Gastric pit epithelial injury | −0.13 | 0.249 | 0.747 |
| Mucosal fibrosis | −0.04 | 0.722 | NS |
| Antrum | |||
| Surface epithelial injury | −0.03 | 0.770 | NS |
| Gastric pit epithelial injury | 0.15 | 0.162 | 0.486 |
| Mucosal fibrosis | −0.01 | 0.903 | NS |
| Inflammatory criteria | −0.12 | 0.269 | 0.269 |
| Fundus | |||
| Intraepithelial lymphocytes | −0.07 | 0.509 | NS |
| Lamina propria LPC | −0.13 | 0.228 | NS |
| Lamina propria eosinophils | 0.14 | 0.204 | NS |
| Lamina propria neutrophils | NA | NA | NA |
| Lamina propria MΦ | 0.07 | 0.486 | NS |
| Lymphoid follicular hyperplasia | −0.01 | 0.978 | NS |
| Antrum | |||
| Intraepithelial lymphocytes | −0.10 | 0.359 | NS |
| Lamina propria LPC | −0.22 | 0.038 | 0.228 |
| Lamina propria eosinophils | −0.03 | 0.789 | NS |
| Lamina propria neutrophils | 0.14 | 0.209 | NS |
| Lamina propria MΦ | −0.03 | 0.812 | NS |
| Lymphoid follicular hyperplasia | −0.10 | 0.369 | NS |
| Duodenum (composite score) | −0.19 | 0.070 | 0.210 |
| Morphologic criteria (sum) | −0.14 | 0.189 | 0.378 |
| Villus stunting | −0.10 | 0.354 | NS |
| Epithelial injury | 0.03 | 0.759 | NS |
| Crypt distension | −0.23 | 0.027 | 0.135 |
| Lacteal dilation | −0.11 | 0.310 | NS |
| Mucosal fibrosis | 0.07 | 0.512 | NS |
| Inflammatory criteria (sum) | −0.14 | 0.189 | 0.378 |
| Intraepithelial lymphocytes | −0.05 | 0.602 | NS |
| Lamina propria LPC | −0.25 | 0.017 | 0.085 |
| Lamina propria eosinophils | 0.01 | 0.902 | NS |
| Lamina propria neutrophils | −0.21 | 0.044 | 0.176 |
| Lamina propria MΦ | 0.12 | 0.256 | 0.768 |
| Ileum (composite score) | 0.11 | 0.629 | NS |
| Morphologic criteria (sum) | 0.09 | 0.670 | NS |
| Villus stunting | 0.13 | 0.545 | NS |
| Epithelial injury | 0.20 | 0.346 | NS |
| Crypt distension | 0.24 | 0.254 | NS |
| Lacteal dilation | −0.25 | 0.238 | NS |
| Mucosal fibrosis | NA | NA | NA |
| Inflammatory criteria (sum) | 0.10 | 0.645 | NS |
| Intraepithelial lymphocytes | 0.04 | 0.843 | NS |
| Lamina propria LPC | 0.17 | 0.417 | NS |
| Lamina propria eosinophils | 0.06 | 0.781 | NS |
| Lamina propria neutrophils | −0.06 | 0.786 | NS |
| Lamina propria MΦ | 0.20 | 0.341 | NS |
| Colon (composite score) | −0.07 | 0.692 | NS |
| Morphologic criteria (sum) | −0.20 | 0.262 | 0.524 |
| Epithelial injury | −0.11 | 0.550 | NS |
| Crypt distension | −0.23 | 0.177 | 0.708 |
| Change in goblet cells | 0.04 | 0.833 | NS |
| Mucosal fibrosis | −0.11 | 0.542 | NS |
| Inflammatory criteria (sum) | 0.08 | 0.649 | NS |
| Intraepithelial lymphocytes | −0.14 | 0.418 | NS |
| Lamina propria LPC | 0.08 | 0.668 | NS |
| Lamina propria eosinophils | 0.15 | 0.389 | NS |
| Lamina propria neutrophils | −0.06 | 0.731 | NS |
| Lamina propria MΦ | 0.02 | 0.910 | NS |
LPC = lymphocytes/plasma cells; MΦ = macrophages; NA = not applicable; NS = not significant; pcorr = Holm–Bonferroni corrected p value (n = 2, 3, 4, 5, or 6). Values in bold indicate significance at p < 0.05.