Table 3.
Characteristics of dogs with food-responsive enteropathy (FRE) or immunosuppressant-responsive/-refractory enteropathy (IRE) with available case outcomes (n = 20).
| Group characteristic | FRE | IRE |
|---|---|---|
| Total number | 5 | 15 |
| Age (y), median (IQR) | 8 (1–10) | 8 (7–10) |
| Sex: male/female | 3/2 | 8/7 |
| Body weight (kg), median (IQR) | 19.4 (9.1–37.6) | 12.4 (4.4–25.0) |
| Follow-up time (mo), median (IQR) | 15 (6–18) | 9 (4–12) |
| CCECAI score, median (IQR) | 6 (3–8) | 9 (5–10) |
| Clinical disease severity, n | ||
| Mild* | 2 (40%) | 4 (27%) |
| Moderate† | 2 (40%) | 2 (13%) |
| Severe‡ | 1 (20%) | 7 (47%) |
| Very severe§ | 0 | 2 (13%) |
| Serum sRAGE (ng/L), median (IQR) | 415 (217–565) | 248 (52–554) |
| > 340 ng/L, n | 3 (60%) | 4 (27%) |
| ≤ 340 ng/L, n | 2 (40%) | 11 (73%) |
| 52–340 ng/L, n | 2 (40%) | 7 (47%) |
| ≤ 52 ng/L, n | 0 (0%) | 4 (27%) |
| Serum albumin (g/L), median (IQR) | 31 (30–35) | 22 (17–29) |
| Hypoalbuminemia, n | 0 | 6 (40%) |
| Mild¦ | − | 4 (27%) |
| Moderate# | − | 0 |
| Severe¶ | − | 2 (13%) |
| Serum cobalamin (ng/L), median (IQR) | 367 (293–872) | 226 (178–331) |
| Hypocobalaminemia, n** | 0 | 8 (53%) |
| Serum folate (µg/L), median (IQR) | 15.1 (12.7–21.2) | 15.8 (9.4–19.7) |
| Hypofolatemia, n | 0 | 3 (20%) |
| Hyperfolatemia, n | 0 | 1 (7%) |
| Serum CRP (mg/L), median (IQR) | 1.4 (0.6–2.8) | 14.3 (8.5–37.8)†† |
| Fecal calprotectin (µg/g), median (IQR) | 0.9 (0.5–1.6) | 1.6 (0.8–17.7) |
| Serum calprotectin (mg/L), median (IQR) | 6.1 (2.6–9.6)‡‡ | 9.3 (4.8–11.1)§§ |
| Fecal S100A12 (ng/g), median (IQR) | 72 (35–193) | 205 (59–1,087) |
| Serum S100A12 (µg/L), median (IQR) | 93 (40–233) | 232 (152–393)¦¦ |
| Fecal α1PI (µg/g), median (IQR) | 8.6 (4.7–20.9) | 11.0 (4.0–23.5) |
| Serum α1PI (mg/L), median (IQR) | 1,478 (1,178–1,781) | 1,173 (855–1,571)## |
CCECAI = canine chronic enteropathy clinical disease activity index; CRP = C-reactive protein; IQR = interquartile range.
*
CCECAI score of 4–5.
†
CCECAI score of 6–8.
‡
CCECAI score of 9–11.
§
CCECAI score of ≥ 12.
¦
Defined as a serum albumin concentration 15–20 g/L.
#
Defined as a serum albumin concentration 12–14.9 g/L.
¶
Defined as a serum albumin concentration < 12 g/L.
**
Defined as a serum cobalamin concentration < 300 ng/L.
††
Available from 14 dogs diagnosed with IRE.
‡‡
Available from 2 dogs with FRE.
§§
Available from 5 dogs with IRE.
¦¦
Available from 11 dogs with IRE.
##
Available from 12 dogs with IRE.