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. 2019 Apr 15;112(1):87–94. doi: 10.1093/jnci/djz065

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Published by Oxford University Press 2019. This work is written by US Government employees and is in the public domain in the US.

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Figure 2. — Manhattan plot of P values from association analysis between DNA methylation and breast cancer status in Sister Study samples (1219 invasive cases and 1224 noncases). The 2095 cytosine-phosphate-gnine sites replicated in the EPIC-Italy dataset are marked in red. Bottom dashed line indicates the false discovery rate threshold of 0.01 and top dashed line indicates Bonferroni P value threshold of 1 × 10^–7. CpG = cytosine-phosphate-gnine.