Table 2.

Function of partner genes related to GREB1 rearrangement

Gene	Encoded protein	Basic function
CTNNB1	β-Catenin	Crucial transcriptional factor in Wingless-Int (Wnt)/β-catenin signaling pathway; transcriptional coactivator for T-cell factor/lymphoid enhancer factor (TCF), and with its transactivation domain, activates transcription initiation, histone methyltransferases, chromatin modification, and transcription facilitation
NCOA1–3	Nuclear Receptor Coactivator 1–3	Transcription factors: coactivate nuclear hormone receptors and mediate steroid/sex-hormone receptor pathways
NR4A3	Nuclear Receptor Subfamily 4 Group A Member 3	Transcription factor: transcriptional activator of the steroid/thyroid hormone nuclear receptor family, with a role in regulating proliferation, survival, and differentiation
SS18	SS18 (or SSXT)	Transcription factor: transcriptional coactivator and a component of the SWI/SNF chromatin-remodeling complex