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. 2020 Aug 31;14:926. doi: 10.3389/fnins.2020.00926

FIGURE 11.

FIGURE 11

Ultrastructural integration of microglia and astrocytes with a perforated polyimide implant. (A) A low magnification cross-section of an implanted PPMP through the perforated segment. The PI “ribs” are encompassed by microglia (dark cytoplasm marked by cyan and typical microglia nuclei - μG marked yellow) and astrocytes (cytoplasm marked pink, and astrocyte nuclei - Ast yellow). (B,C) high magnification of microglia (cyan) adheres to a gold electrode and PI. Note the typical nuclear chromatin distribution of the microglia (yellow) and the lack of obvious extracellular space between the microglia membrane, the gold electrode and the PI surfaces. Extracellular space between the microglia and nearby cell is marked in blue. The images were prepared 14 days after the PPMP implantation. PI- polyimide, N - nucleus, RER- rough endoplasmic reticulum, Cl -conducting line, μG- microglia, Ast- astrocyte. Note an unmarked copy of this figure is presented as Supplementary Figure S7.