. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Alcohol Clin Exp Res. 2019 Oct 1;43(11):2374–2383. doi: 10.1111/acer.14186

Table 5.

Study highlights

Study Highlights
PLWH study participants with elevated PEth levels (representative of recent excessive alcohol consumption) had lower levels of serum bone formation marker osteocalcin compared to subjects with non-detectable PEth Self-reported alcohol consumption (time-linked follow back, AUDIT, AUDIT-C), in addition to PEth, was negatively associated with serum osteocalcin after adjusting for several relevant covariates Adjusted analyses found alcohol consumption to be associated with a significant increase in circulating oxidative stress marker 4-HNE 4-HNE was not independently associated with osteocalcin, implying independent effects of alcohol on oxidative stress and altered bone turnover in PLWH

Study Highlights

PLWH study participants with elevated PEth levels (representative of recent excessive alcohol consumption) had lower levels of serum bone formation marker osteocalcin compared to subjects with non-detectable PEth
Self-reported alcohol consumption (time-linked follow back, AUDIT, AUDIT-C), in addition to PEth, was negatively associated with serum osteocalcin after adjusting for several relevant covariates
Adjusted analyses found alcohol consumption to be associated with a significant increase in circulating oxidative stress marker 4-HNE
4-HNE was not independently associated with osteocalcin, implying independent effects of alcohol on oxidative stress and altered bone turnover in PLWH