Table 2. Factors Associated With SSRI Use After Intracerebral Hemorrhage.
| Variable | SSRI users (n = 281) | No SSRI exposure (n = 998) | Univariable P value | Multivariable | |
|---|---|---|---|---|---|
| OR (95% CI) | P value | ||||
| Education, ≥12 y, No. (%) | 187 (67) | 602 (60) | .059 | 1.74 (0.93-3.25) | .09 |
| History of pre-ICH depression, No. (%) | 101 (36) | 138 (14) | <.001 | 3.49 (1.89-8.15) | .005 |
| Discharge mRS score, median (IQR)a | 4 (3-5) | 4 (3-4) | .004 | 1.83 (1.20-2.80) | .007 |
| ICH volume, median (IQR)b | 18.5 (4.1-26.8) | 14.2 (3.5-21.8) | .001 | 1.35 (0.93-1.95) | .15 |
| Prior ICH, No. (%) | 36 (13) | 40 (4) | <.001 | 3.18 (1.54-6.55) | .002 |
| Prior ischemic stroke or TIA, No. (%) | 34 (12) | 80 (8) | .007 | 1.69 (1.11-2.57) | .02 |
Abbreviations: ICH, intracerebral hemorrhage; IQR, interquartile range; mRS, modified Rankin Scale, OR, odds ratio; SSRI, selective serotonin reuptake inhibitor; TIA, transient ischemic attack.
a
Effect size calculated for 1-point increase in mRS score.
b
Effect size calculated for 10-cm3 increase in ICH volume.