Table 1.

Association Between Gut Microbiota Composition and Weight, Plasma GDF-15, and sCD14 Variation After Metformin Treatment

Stool Microbiota Composition at V2					Fold Change at V2
Class	Order	Family	Genus	Species	Weight	GDF-15	sCD14
Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	Fragilis	–0.24	0.47 *	0.62 **
			Bacteroides	Thetaiotaomicron	–0.38	0.53 *	0.30
		Muribaculaceae	Muribaculaceae_g	Muribaculaceae_g_s	0.11	–0.43 *	–0.13
		Prevotellaceae	Prevotella_7	Prevotella_7_s	0.42 *	–0.40	–0.28
			Prevotellaceae_g	Prevotellaceae_g_s	0.14	–0.48 *	–0.37
		Rikenellaceae	Alistipes	Alistipes_s	–0.50 *	0.27	0.44 *
			Alistipes	Putredinis	–0.23	0.43 *	–0.20
			Rikenellaceae_RC9_gut_group	Rikenellaceae_RC9_gut_group_s	0.22	–0.20	–0.49 *
Clostridia	Clostridiales	Lachnospiraceae	Blautia	Obeum	0.44 *	0.01	0.05
			CAG-56	CAG-56_s	0.19	0.55 **	0.32
			Hungatella	Hathewayi	–0.45 *	0.21	0.28
			Lachnospiraceae_g	Lachnospiraceae_g_s	–0.43 *	0.01	0.35
			Lachnospiraceae_ND3007_group	Lachnospiraceae_ND3007_group_s	0.05	–0.43 *	0.11
			Lachnospira	Lachnospira_s	0.02	–0.54 **	–0.04
		Ruminococcaceae	Faecalibacterium	CM04-06	0.10	–0.42 *	–0.12
			Oscillibacter	Oscillibacter_s	–0.52 *	0.09	0.23
			Ruminiclostridium_5	Ruminiclostridium_5_s	0.25	–0.65 **	–0.07
Negativicutes	Selenomonadales	Acidaminococcaceae	Phascolarctobacterium	Faecium	–0.44 *	0.00	–0.03
Alphaproteobacteria	Rhodospirillales	Rhodospirillales_f	Rhodospirillales_f_g	Rhodospirillales_f_g_s	–0.18	0.51 *	0.12
Deltaproteobacteria	Desulfovibrionales	Desulfovibrionaceae	Bilophila	Wadsworthia	0.44 *	0.00	0.07
Gamma proteobacteria	Betaproteobacteriales	Burkholderiaceae	Parasutterella	Excrementihominis	–0.47 *	0.01	0.25
	Betaproteobacteriales	Burkholderiaceae	Sutterella	Sutterella_s	0.04	–0 .45 *	–0.22

Abbreviation: V2, after metformin treatment.

Significant values are indicated in bold. *P < .05; **P < .01; ***P < .001. Spearman’s test.