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. 2020 Sep 14;15(9):e0239037. doi: 10.1371/journal.pone.0239037

Table 4. Factors associated with recurrent preterm births among women delivered at KCMC (N = 5946).

Characteristics Recurrence of Preterm birth
Total (N) n (%) cRR,95% CI P-value
in previous birth)
Term delivery 5,405 525 (9.7) 1
Preterm delivery 541 132(24.4) 2.51[2.11,2.97] <0.001
Pre-eclampsia
No 5,763 622(10.8) 1
Yes 183 35(19.1) 1.77[1.29,2.41] <0.001
Inter-pregnancy interval (months)
24–59 2,805 281(10) 1
<24 1,902 227(11.9) 1.19[1.01,1.40] 0.036
>59 1,049 130(12.4) 1.24[1.02,1.51] 0.034
Birth weight
Normal birth weight 5,441 538(9.9) 1
Low birth weight 442 98(22.2) 2.24[1.85,2.71] <0.001
Very low birth weight 53 19(35.8) 3.62[2.51,5.21] 0.001
Extremely low birth weight 10 2(20) 2.02[0.58,6.99] 0.267
Premature rupture of membrane
No 5,873 642(10.9) 1
Yes 73 15(20.5) 1.00[0.57,1.76] 0.988
Clinical subtypes
Spontaneous delivery 359 78(21.7) 1
Medically indicated delivery 178 54(30.3) 1.40[1.03,1.88] 0.028
Term delivery 5409 527(9.74) 0.45[0.36,0.57] <0.001
Mother’s education
No formal education 56 7(12.5) 1
Primary education 2,880 350(12.2) 0.98[0.49,1.96] 0.945
Secondary education 872 105(12) 0.96[0.47,1.96] 0.906
Tertiary education 2,138 195(9.1) 0.73[0.36,1.48] 0.384
Alcohol use
No 4,196 485(11.6) 1
Yes 1,750 172(9.8) 0.85[0.72,1.00] 0.055
Mother’s age (years)
15-<25 786 100(12.7) 1
25–35 3,848 404(10.5) 0.82[0.67,1.01] 0.059
>35 1,303 152(11.7) 0.92[0.72,1.16] 0.46

cRR: Crude risk ratio