Figure 1. Flow of Participants in a Study of the Effect of Tranexamic Acid vs Placebo on Neurologic Outcomes in Patients With Traumatic Brain Injury.

^aPatients for whom the blinded study drug was not infused are not included in analyses.

^bPatients in this category may have had a seizure prior to study drug administration or seizure-like behavior that was not managed and thus are not necessarily adverse events.

^cIncorrect in-hospital assignment was made for 1 patient, who received approximately 125 mg of tranexamic acid prior to infusion being stopped.