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. 2020 Sep 10;477(17):3287–3297. doi: 10.1042/BCJ20200556

Figure 2. Interactions of HyBcl-2-4 with BH3 domain peptides of hydra encoded pro-apoptotic Bcl-2 proteins.

Figure 2.

(a) ITC thermograms of the interaction between HyBcl-2-4 for BH3 domain peptides from hydra and human BH3 peptides (26-mers, except for a Bid 34-mer and Bax 28-mers). (b) Interactions of HyBcl-2-4 with BH3 domain peptides of human pro-apoptotic Bcl-2 proteins as well as interactions of human Bcl-2, Bcl-xL, Bcl-w, Mcl-1 and A1 with BH3 domain peptides of hydra encoded pro-apoptotic Bcl-2 proteins. All affinities were measured using ITC. Tabulation of affinity (KD) values (nM) are the means of 3 experiments ± SD. NB: no binding detected.