Figure 5. Small compounds inhibit importin α-ChREBP-NLS peptides interaction.

FP measurements were carried out as described under Experimental procedure. (A) Dose response curves of compounds 1 (blue), and 2 (red). The double reciprocal plots of the FP reaction between importin α-ChREBP-NLS in the presence of varying concentrations (0 µM (blue ◇), 0.6 µM(red □) and 2 µM (green △) of compound 1 (B), and compound 2 in the presence of (0 µM (blue ◇), 0.6 µM (red □) and 2 µM (green △) (C).