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(A) The nuclear localization of ChREBP was determined in the reaction mixture containing GFP-ChREBP in the presence of compound 1 (3 µM; O) and compound 2 (3 µM; ◇), under the conditions described under Experimental Procedure. (B) The transcriptional activity of ChREBP was measured in the presence of varying concentrations of compound 1 and compound 2.
