Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 24;295(37):12868–12884. doi: 10.1074/jbc.RA120.012522

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Duan et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

Figure 9. — The molecular mechanism by which ADSC-derived EVs alleviate injury caused by DN. EVs derived from ADSCs enter mouse glomerular podocytes, MP5 cells. MiR-26a-5p contained in the ADSC-derived EVs targets and inhibits TLR4, inactivating the NF-κB/VEGFA pathway in HG-induced MP5 cells, characterized by decreased IKKβ, IκBα, and p65 protein expression and a decrease in the extent of the phosphorylation of those proteins. This leads to enhanced viability and suppresses apoptosis of MP5 cells.