Table 3.
GTP analogs, substituted group at the 2′ position and properties associated with these groups
S. No. | GTP analogs | Group at 2′ position | Property conferred |
---|---|---|---|
1 | GTP | OH | 3′-Endo conformation |
2 | dGTP | H | 3′-Exo conformation |
3 | 2′-F dGTP | F | 3′-Endo conformation |
4 | 2′-NH2 dGTP | NH2 | Can accept and donate H-bond |
5 | 2′-O-Me dGTP | O-CH3 | Can accept H-bond but cannot transfer proton |