Table 1.
IC50 Values for Heparin and HS as Competitive Inhibitors of S Protein Binding
| Cells | Inhibitor | IC50 (μg/mL) | 95% CI (μg/mL) | R2 of fit |
|---|---|---|---|---|
| H1299 | CHO HS | 139 | 18–∞ | 0.803 |
| heparin | 0.03 | 0.02–0.04 | 0.991 | |
| MST heparin | 0.12 | 0.09–0.15 | 0.991 | |
| split-glycol heparin | 0.04 | 0.03–0.06 | 0.971 | |
| kidney HS | 8.4 | 3.7–25 | 0.749 | |
| liver HS | 62 | 15–∞ | 0.627 | |
| lung HS | 2.1 | 0.78–5.8 | 0.828 | |
| tonsil HS | 2.5 | 0.74–7.5 | 0.838 | |
| A549 | CHO HS | 19 | 8.6–49 | 0.907 |
| heparin | 0.01 | 0.010–0.013 | 0.997 | |
| MST heparin | 0.03 | 0.026–0.032 | 0.997 | |
| split-glycol heparin | 0.01 | 0.007–0.008 | 0.999 |
IC50 values and confidence intervals were determined using non-linear regression using the inhibitor versus response least-squares fit algorithm. Related to Figure 4.