TABLE 1.
Comparison of Odds Ratios and Area Under Receiver Operating Characteristic Curve (AUC) Across Time at ICP Levels for Mortality and Poor mRS (4–6) at Days 30 and 180
| ICP Threshold (mm Hg) | Odds Ratio (95% CI) | p | AUC | Correctly Classified (%) |
|---|---|---|---|---|
| Day 30 Mortality | ||||
| >10 | 1.12 (0.97–1.30) | 0.11 | 0.828 | 88.45 |
| >15 | 1.14 (0.98–1.33) | 0.09 | 0.825 | 88.67 |
| >18 | 1.27 (1.03–1.57) | 0.02 | 0.826 | 89.98 |
| >20 | 1.48 (1.15–1.90) | 0.002 | 0.828 | 90.20 |
| >22 | 1.63 (1.20–2.22) | 0.002 | 0.828 | 90.63 |
| >25 | 2.09 (1.38–3.15) | <0.001 | 0.831 | 90.20 |
| >30 | 2.47 (1.33–4.59) | 0.004 | 0.832 | 89.54 |
| >20 in spans | 1.77 (1.22–2.58) | 0.003 | 0.838 | 88.67 |
| Day 180 Mortality | ||||
| >10 | 1.04 (0.94 – 1.14) | 0.48 | 0.772 | 81.28 |
| >15 | 1.08 (0.96–1.21) | 0.19 | 0.772 | 82.16 |
| >18 | 1.15 (0.98–1.35) | 0.09 | 0.772 | 83.04 |
| >20 | 1.21 (0.99–1.49) | 0.06 | 0.772 | 82.60 |
| >22 | 1.26 (0.98–1.62) | 0.08 | 0.772 | 82.60 |
| >25 | 1.34 (0.95–1.88) | 0.09 | 0.771 | 81.50 |
| >30 | 1.42 (0.84–2.39) | 0.19 | 0.773 | 81.72 |
| >20 in spans | 1.43 (1.03–1.99) | 0.03 | 0.785 | 83.44 |
| Day 30 Poor mRS | ||||
| >10 | 1.06 (0.94–1.20) | 0.34 | 0.895 | 86.75 |
| >15 | 1.07 (0.94–1.22) | 0.33 | 0.895 | 86.75 |
| >18 | 1.11 (0.92–1.35) | 0.27 | 0.895 | 86.98 |
| >20 | 1.17 (0.89–1.53) | 0.27 | 0.895 | 86.75 |
| >22 | 1.12 (0.62–1.30) | 0.55 | 0.894 | 86.98 |
| >25 | 1.10 (0.65–1.88) | 0.71 | 0.893 | 86.98 |
| >30 | 0.85 (0.37–1.96) | 0.71 | 0.895 | 86.75 |
| >20 in spans | 1.55 (0.92–2.62) | 0.10 | 0.899 | 87.42 |
| Day 180 Poor mRS | ||||
| >10 | 0.99 (0.90–1.09) | 0.90 | 0.854 | 77.11 |
| >15 | 1.08 (0.97–1.20) | 0.16 | 0.856 | 78.00 |
| >18 | 1.11 (0.96–1.27) | 0.16 | 0.856 | 78.44 |
| >20 | 1.14 (0.95–1.37) | 0.16 | 0.856 | 78.22 |
| >22 | 1.11 (0.88–1.40) | 0.39 | 0.855 | 77.78 |
| >25 | 1.07 (0.77–1.49) | 0.70 | 0.854 | 77.78 |
| >30 | 1.12 (0.65–1.93) | 0.68 | 0.854 | 77.56 |
| >20 in spans | 1.21 (0.91–1.60) | 0.19 | 0.855 | 78.22 |
CPP = cerebral perfusion pressure, ICP = intracranial pressure. All models adjusted for number of ICP/CPP readings per patient, age, Glasgow Coma Scale, intracerebral hemorrhage (ICH) and intraventricular hemorrhage volume, thalamic ICH location, treatment group, and admission systolic blood pressure.