TABLE 2.
Comparison of Odds Ratios and Area Under Receiver Operating Characteristic Curve (AUC) Across Time at CPP Levels for Mortality and Poor mRS (4–6) at Days 30 and 180
| CPP Threshold (mm Hg) | Odds Ratio (95% CI) | p | AUC | Correctly Classified (%) |
|---|---|---|---|---|
| Day 30 Mortality | ||||
| <90 | 1.18 (1.01–1.37) | 0.04 | 0.835 | 89.96 |
| <85 | 1.17 (1.02–1.34) | 0.02 | 0.838 | 89.52 |
| <80 | 1.17 (1.02–1.34) | 0.03 | 0.836 | 89.30 |
| <75 | 1.22 (1.03–1.44) | 0.02 | 0.836 | 89.30 |
| <70 | 1.36 (1.07–1.74) | 0.01 | 0.838 | 88.43 |
| <65 | 1.77 (1.22–2.57) | 0.003 | 0.839 | 89.52 |
| <60 | 2.82 (1.24–6.42) | 0.01 | 0.841 | 89.30 |
| <70 in spans | 1.58 (0.97–2.59) | 0.07 | 0.841 | 88.86 |
| <70 + ICP >20 | 2.13 (1.46–3.10) | <0.001 | 0.838 | 90.17 |
| Day 180 Mortality | ||||
| <90 | 1.12 (1.01–1.23) | 0.03 | 0.781 | 82.34 |
| <85 | 1.11 (1.01–1.08) | 0.03 | 0.781 | 82.78 |
| <80 | 1.14 (1.03–1.26) | 0.01 | 0.782 | 82.34 |
| <75 | 1.17 (1.04–1.33) | 0.01 | 0.783 | 82.12 |
| <70 | 1.22 (1.01–1.47) | 0.04 | 0.779 | 82.34 |
| <65 | 1.45 (1.05–2.00) | 0.02 | 0.779 | 82.56 |
| <60 | 1.55 (0.82–2.93) | 0.18 | 0.775 | 81.90 |
| <70 in spans | 1.28 (0.88–1.87) | 0.19 | 0.788 | 81.22 |
| <70 + ICP >20 | 1.41 (0.99–2.00) | 0.06 | 0.782 | 82.75 |
| Day 30 Poor mRS | ||||
| <90 | 1.20 (1.08–1.33) | 0.001 | 0.903 | 88.94 |
| <85 | 1.21 (1.09–1.36) | 0.001 | 0.903 | 88.50 |
| <80 | 1.30 (1.13–1.50) | <0.001 | 0.905 | 88.50 |
| <75 | 1.51 (1.20–1.90) | <0.001 | 0.906 | 87.61 |
| <70 | 1.73 (1.18–2.55) | 0.005 | 0.901 | 86.06 |
| <65 | 2.32 (1.08–4.97) | 0.03 | 0.900 | 85.84 |
| <60 | 8.25 (0.74–91.55) | 0.09 | 0.897 | 85.62 |
| <70 in spans | 2.76 (0.75–10.23) | 0.13 | 0.900 | 86.95 |
| <60 + ICP >20 | 13.59 (1.23–150.62) | 0.03 | 0.897 | 87.39 |
| Day 180 Poor mRS | ||||
| <90 | 1.08 (0.98–1.18) | 0.11 | 0.856 | 77.28 |
| <85 | 1.07 (0.98–1.18) | 0.14 | 0.855 | 77.10 |
| <80 | 1.10 (0.98–1.23) | 0.08 | 0.856 | 77.51 |
| <75 | 1.15 (0.99–1.33) | 0.01 | 0.856 | 77.28 |
| <70 | 1.18 (0.95–1.46) | 0.14 | 0.855 | 77.28 |
| <65 | 1.53 (1.02–2.29) | 0.04 | 0.856 | 77.73 |
| <60 | 1.87 (0.82–4.30) | 0.14 | 0.855 | 77.06 |
| <70 in spans | 1.27 (0.77–2.08) | 0.35 | 0.856 | 77.95 |
| <60 + ICP >20 | 1.82 (0.59–5.65) | 0.30 | 0.854 | 76.84 |
CPP = cerebral perfusion pressure, ICP = intracranial pressure. All models adjusted for number of ICP/CPP readings per patient, age, Glasgow Coma Scale, intracerebral hemorrhage (ICH) and intraventricular hemorrhage volume, thalamic ICH location, treatment group, and admission systolic blood pressure.