Table 3.

Univariate and Multivariate Analyses of Overall Survival in Patients with Oral Cavity Squamous Cell Carcinoma After Treatment

Variables	Univariate			Multivariate
	Hazard Ratio	95% CI	P-value	Hazard Ratio	95% CI	P-value
Age (years)	1.002	0.984–1.020	0.8445	1.011	0.990–1.033	0.2933
Sex
Male	Reference			Reference
Female	0.834	0.430–1.619	0.5921	1.033	0.514–2.076	0.9279
Overall pathological stage
I–II	Reference			Reference
III–IV	5.449	3.145–9.440	<0.0001b	2.572	1.321–5.007	0.0054
Perineural invasion
No	Reference
Yes	1.926	1.453–2.553	<0.0001b
ENE
(-)	Reference			Reference
(+)	5.952	3.799–9.325	<0.0001b	3.084	1.827–5.206	<0.0001b
Tumor depth (mm)
≤5 mma	Reference			Reference
>5 mma	5.460	2.206–13.513	0.0002b	2.332	0.872–6.234	0.0916
CD3
<2016/mm2a	Reference
>2016/mm2a	0.690	0.444–1.071	0.0980
CD8
<1125/mm2a	Reference
>1125/mm2a	0.597	0.383–0.930	0.0227b
CD8/CD3
<0.592a	Reference
>0.592a	0.652	0.419–1.015	0.0580
Score
2	Reference			Reference
1	0.657	0.388–1.111	0.1174	0.718	0.420–1.229	0.2270
0	0.512	0.301–0.871	0.0135b	0.559	0.324–0.965	0.0369b

Notes: ^aMedian. ^bStatistically significant

Abbreviations: CI, confidence interval; ENE, extranodal extension.