Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 7;15:6579–6592. doi: 10.2147/IJN.S261041

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Darling et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Polyanhydride nanoparticles induce effective CD8⁺ T cell memory as compared to CpG ODN. C57BL/6 female mice (n=12) were immunized subcutaneously with formulations consisting of 75 μg soluble Ova plus 500 μg of 20:80 CPTEG:CPH polyanhydride nanoparticles encapsulating 25 μg Ova (NP); 100 μg soluble Ova adjuvanted with 20 μg CpG ODN (CpG); a combination of 75 μg soluble Ova plus 500 μg of 20:80 CPTEG:CPH polyanhydride nanoparticles encapsulating 25 μg Ova plus 20 μg CpG ODN (NP+CpG); or PBS control. Mice were challenged subcutaneously in the flank with E.G7 Ova-expressing tumor cells 42 days post-immunization and (A) tumor volume of individual mice was tracked. (B) Survival was evaluated 30 days post-challenge. Significance from PBS control was determined using a Log rank (Mantel-Cox) test with a Bonferroni correction for multiple (3) comparisons. Significance from naïve control group is indicated in the treatment group legend as follows *p ≤ 0.016. Median survival of each group is also reported parenthetically.