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. 2020 Sep 8;13:8951–8961. doi: 10.2147/OTT.S266073

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© 2020 Zhang et al.

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Downregulation of SREBP suppressed the migration and invasion abilities of NSCLC cells. (A and B) the expression of epithelial marker protein -cadherin was increased, and the expression of mesenchymal marker proteins N-cadherin and Vimentin were decreased. Cell migration was detected using wound healing assay. This result was verified by Western Blot and immunofluorescence. (C) Scratch wound healing assay. 24 hours after the scratch culture, the extent of cell migration was photographed at the indicated times. (D) Cell invasion was detected using transwell assay (a: transwell assay, b: transwell invasion assay with matrigel).