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. 2020 Sep 10;13:9015–9027. doi: 10.2147/OTT.S268678

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© 2020 Li et al.

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Upregulation of high mobility group box 1 (HMGB1) counteracts long intergenic noncoding (LINC) 00525 deficiency-induced suppression of chordoma cell proliferation, migration, and invasion, as well as the increase in cell apoptosis. (A) Western blotting was performed to quantify HMGB1 protein levels in U-CH1 and U-CH2 cells transfected with pcDNA3.1-HMGB1 or pcDNA3.1. (B, C) CCK-8 assay and flow cytometric analysis were carried out to assess the proliferation and apoptosis of U-CH1 and U-CH2 cells after co-transfection with si-LINC00525 and pcDNA3.1-HMGB1 or pcDNA3.1. (D, E) The assessment of migratory and invasive abilities in the cells described above was performed by migration and invasion assays. **P < 0.01.