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. 2020 Sep 10;13:9015–9027. doi: 10.2147/OTT.S268678

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© 2020 Li et al.

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Loss of long intergenic noncoding RNA (LINC) 00525 suppresses chordoma tumor growth in vivo. (A) Growth curve of tumor xenograft volumes, which were monitored every 5 days. (B) Representative images of tumor xenografts collected from short hairpin RNA (sh)-LINC00525 and control (sh-NC) groups. (C) Weights of tumor xenografts in the sh-LINC00525 and sh-NC groups. (D, E) LINC00525 and miR-505-3p expression in tumor xenografts was measured by RT-qPCR. (F, G) HMGB1 mRNA and protein expression in tumor xenografts engineered to stably express sh-LINC00525 or sh-NC were detected using RT-qPCR and Western blotting, respectively. **P < 0.01.