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. 2020 Sep 10;12:8363–8377. doi: 10.2147/CMAR.S271021

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© 2020 Fan et al.

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DARS-AS1 depletion suppresses PCa cell proliferation, migration, and invasion and promotes cell apoptosis. (A) DARS-AS1 expression in PCa tissues and normal tissues was determined using TCGA and GTEx databases. (B) RT-qPCR analysis was performed to detect DARS-AS1 expression in 53 pairs of PCa tissues and adjacent normal tissues. (C) DARS-AS1 expression in four PCa cell lines and the human normal prostate epithelial cell line RWPE-1. (D, E) GEPIA was used to examine the correlation between DARS-AS1 expression and overall survival and disease-free survival in PCa. (F) The efficiency of DARS-AS1 silencing in PC-3 and DU145 cells by si-DARS-AS1 was evaluated by RT-qPCR. (G) CCK-8 assay was performed to determine the proliferation of PC-3 and DU145 cells after DARS-AS1 downregulation. (H) Flow cytometry analysis revealed the effect of DARS-AS1 silencing on the apoptosis of PC-3 and DU145 cells. (I, J) The migratory and invasive capacities of DARS-AS1-silenced PC-3 and DU145 cells were measured via Transwell assays. **P < 0.01.