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. 2020 Sep 9;13:507–518. doi: 10.2147/JIR.S267280

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© 2020 Shibabaw et al.

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Proposed mechanism of SARS-CoV-2 induced inhibition of IFN production and it signaling during action on target cells. Some SARS-CoV-2 genes act as virulence factor that antagonize innate immune response by inhibiting IFN gene expressions such as Nsp16, Nsp3, and ORF9. Other gene components of the SARS virus act as inhibitors of INF signaling on different target cells mainly ORF9, ORF3a and Nsp1.