Table 3. Pentapeptide sharing between immunoreactive EBV epitopes and human proteins implicated in lymphomagenesis/leukemogenesis.
| Shared peptides | Lymphoma/Leukemia-related proteins containing EBV epitope peptide(s) a | Ref b |
|---|---|---|
| LSPLL, RRQKR, LALRA, KEVLE, LGLGD, GNLVT, SLESV, LPTLL, PETVP, ALYLQ, ARVKE, PSLKL, KILLA, NPETL, EGLKD, LYLQQ, QKRPS, VAKVA, DRHSD, LQAIG, LSQVC, RPSCI | ATM: Serine-protein kinase ATM | 52 |
| PLPPP, PPLPP, LPTLL, REAIL, AERHG, CKKDH | BANK1: B-cell scaffold protein with ankyrin repeats | 53 54 |
| EEEEE, PPLPP, GAGGG, AGAGG, GAGGA, AGGGA, GRGGG, PPPVS, LSAAS, PPLGP, PPVSP, EPGPA, PVSPG, SSLTP, TPPPQ, GDDDD, AVAQS, DPSLG, GNSST, PGLFP, SEPVE, DDAGG, DDDAG | BC11B: B-cell lymphoma/leukemia 11B | 55 56 57 |
| SSSEE, GPPSP, APAST, GPEAR, PCPQA, PQARL, RFIQA | BCL6B: B-cell/lymphoma 6 member B protein | 58 59 60 61 62 |
| SPSPP, PLPPV, GSGAG, PAGSL, PVPPP, EPGPA, EQASL, EGTRL, LDLDF, LNQNL, VLQKL | BIN1: Myc box-dependent-interacting protein 1 | 63 |
| LLLLL, LRLLL, RLRLL, KEDDG, EGGQN | CADM1: Cell adhesion molecule 1 | 64 |
| PPPPP, LPPPP, GSGSG, GGGSG, GAGGG, GSGGS, SGGSG, GGSGS, SGSGG, LPPVP, PPVPA, PVPPT, QQGSG, CTPGD, PYILD | CBL: E3 ubiquitin-protein ligase CBL | 65 |
| PPPLP, PPGPS, LSPLS, SSPQP, ATSGA, ENLLD, EENLL, SPVLG, AFEEV, GPQDP, YDAPG | CRTC2: CREB-regulated transcription coactivator 2 | 66 |
| LLARL, GASGS, VAGLL, PLHAL, LARLR, SGASP, CGLLR, VPKPR, FIRRL, TDGKT, TPLLT, ALIKT, SSCNS | DAPK1: Death-associated protein kinase 1 | 67 68 |
| EEEAE, FGLSR, SDLSR, SLESV, KAIEE, VIQLV, IIAVV, VMDLL, IAVVA, IKAIE, ESFTQ, QDVGA, RLFAA, TTGGK, VIKAI, SFTQG | EPHA7: Ephrin type-A receptor 7 (998 aa) | 69 |
| LLLLL, PPPPP, LPPPP, ALLLL, LALLL, PPPPS, PPLPP, FPPPP, SLSST, GSPPR, PPQVP, SPSDS, TLSPS, TSEPV, SEDDP, ESVDV, GTPPQ, TDGGG, TSVVQ, VYAAS, EDDPQ, PSELD, DLRPL, FVGDY, KGTPP, PRLFA, VCSVA, HSPVV, ILQIS, LYEAS, PYEAF | FAT1: Protocadherin Fat 1 | 70 71 |
| PPPPP, GGGGG, EEEEA, AAAAV, SSSEE, GGSGS, GGGGD, RGGSG, GAPGG, ASGPG, LPGVP, VSPAV, PGGLG, VEAHV, GGDGD, LRAAT, ERPLA, FPEGV, GGDKV | HIC1: Hypermethylated in cancer 1 protein | 72 |
| PPRPP, RRRKG, ATAAA, SVSQP, AEVLK, LLQTE, SHTAT | KDM6A: Lysine-specific demethylase 6A | 73 74 |
| PPPPP, QPPPP, SPPPP, SSSSA, SSSAP, PTPPP, GAPAA, KKRKR, RGGRG, GGRGR, PPPPY, SSSAG, GRGGR, LPPTP, APPTP, PPLGP, PTPLP, SGSPP, PQPPL, SQASA, DDEDL, STSVP, LPGVS, SSGTA, LTPRP, RPRGA, RQRSR, SGLGT, TPRPP, TPRPS, TSVPS, VTLPL, DLILQ, GTPRP, TPRPV, IAVSS, LDTED, TPRPR, LGATI, SAPRK, EGVEV, LSPAN, LSSCP, MQPPP, SLIQL, AKIEA, EDLFG, EEVEN, QGVQV, TPRSQ, VEDLF, LGLYA, PQSGP, DSREG, VSTAD, GPADD, PADDP, QSLIQ, VFPKD, DTDSL, GTFKP, IPQTL, PLQHW, TGQGK, EQHGM, IDDNS, LRPQW, QRHSD, TFKPP, GPRHT | KMT2C: Histone-lysine N -methyltransferase 2C | 75 76 |
| EEEEE, QPPPP, PLPPP, SAAAA, LRLLL, PAPAA, PAAAP, PTPPP, APPAP, GRGRG, PPSPG, PSPGS, PSPPP, RGRGR, SPLLP, AAPPA, GPAGP, LLAAL, PAQPP, SLGLA, LAPSP, LSPLL, PGPAG, SPSQS, SQSSS, GGRGR, GLPPP, PQGPP, RLRLL, LPPTP, LRSLG, PTLLL, SPSSQ, TPPPS, ALAPS, EGLRA, GPQPP, PEPPT, PLTEP, SSGSP, AASED, APVAP, AVGPP, DDEEL, ESPAR, GAHGG, GPPRL, KKRKR, LTPRP, PALDD, PPPGR, PPQGP, PPQVP, PPTQH, PTLGK, SDEAE, SPLLG, TPHTK, APYPG, ARPPE, ASDRL, CPSLD, DAAAR, EERPP, EGEGD, EGPST, EPRLA, FPDTK, FPEGL, GPLAI, GPWDP, GTQDP, IKVIE, LGLYA, LRLTP, LSPVI, PLLTV, PMSPP, PPTHP, PPVPQ, PQPLM, PQQPM, PSRPQ, QALAP, QEPPP, QTNQA, RGAFG, RPEFV, SDALG, SPVTP, SQTEL, SRVPA, SYTDP, TGSGG, TTPAG | KMT2D: Histone-lysine N -methyltransferase 2D | 77 78 79 |
| GGGGG, GGGGS, GGGGA, AGGGG, GGSGG, GGGSG, GAGGG, GGAGG, AGAGA, PPPEP, LRALL, LALRA, LTPPS, RALLA, RLLLK, PQAPE, TPLDL, GPETR, RVGAD | NFKB2: Nuclear factor NF-kappa-B p100 subunit | 80 81 82 83 |
| AAAPA, GAAAS, PAPGL, LLGGG, TPSPS, SLPHP, PHLPP, GSPTA, PLTSE, RDSYA, TTLAA, YPGYA, HRDSY, SYPGY | PRDM1: PR domain zinc finger protein 1 | 84 |
| EEEEE, PSPPP, APAAA, SPSPP, PSPSP, SPSPS, PLDLS, DEGEE, LDLSV, LLTPV, PTVSP, KQLLQ, VLDLS, LTPVT, TVSPS, VTEDL, AIEEE, TSEET, PAPTV, TPVTV, EAVSF, FKPPP, SFKPP, NIPQT, YSLRL, PALRD, RSQVK, PFVGD | PRDM2: domain zinc finger PR protein 2 | 85 86 87 88 |
| SSSSA, SPLLP, SSSAP, LSPLL, GTPSG, LQSET, PVSRF, AEGKL, PLRPT | SOCS6: Suppressor of cytokine signaling 6 | 68 |
| KKRKR, AGAAR, LQSLA, TSPTS, RSLLT, LSLVF, AGPSV, DPVHG, GPSVA, QATLG, TQLTQ, DLQDP, LEKQS, PVQGE, QERDV, PKTAS, PLTQP, NIEEF, TPHQP, SHETP | TET1: Methylcytosine dioxygenase TET1 | 89 |
| PPPLP, PPPPS, SPPPP, SSSEE, ELLEK, SASGS, QSSHL, APGGS, LQAPG, KLSSL, PPSQL, APPSQ, HLLQH, QQASV, VTKQE, VTVLT, PPTQH, PVTVL, GIKRT | TET2: Methylcytosine dioxygenase TET2 | 90 |
| PPPPP, LPPPP, PLPPP, PPPLP, PPLPP, PPPPS, GGGRG, APGGG, GLPAP, QPPPQ, PAPGP, PRGPP, PPSSG, SLGLA, LPAPG, LPPVP, PLPPV, PPPSR, GGRPG, PPPGR, DLRSL, VGPLS, PMPPP, SEGLV, SGNGP, ADIGA, DIGAP, GGDQG, PVGPL | WASP: Wiskott-Aldrich syndrome protein | 91 |
a
Human proteins reported by UniProt entry names.
b
Further references on the function/disease association at www.uniprot.org , OMIM, and PubMed resources.