TABLE 3.
Predictors of ORN Recurrence-Free Survival
| Log-rank analysis of RFS | Cox regression analysis of RFS | |||
|---|---|---|---|---|
| Variable | Median RFS (months) | P value | HR (95% CI) | P value |
| Patient characteristics | ||||
| Age | ||||
| Below 65 | 69.3 | .052 | .16 (.02-1.32) | .088 |
| 65 or above | 90.0 | |||
| Sex | ||||
| Male | 25.9 | .073 | .25 (.047-1.29) | .097 |
| Female | 110.7 | |||
| Type I/II diabetes | ||||
| Yes | N/A | .46 | .044 (0-13 976.2) | .63 |
| No | N/A | |||
| History of smoking | ||||
| Yes | 44.02 | .19 | 2.65 (.588-11.945) | .21 |
| No | 105.59 | |||
| History of COPD | ||||
| Yes | 18.74 | .72 | .68 (.081-5.63) | .72 |
| No | 89.04 | |||
| History of cardiac disease | ||||
| Yes | 76.8 | .54 | .52 (.062-4.39) | .55 |
| No | 86.9 | |||
| Primary cancer history | ||||
| Neoadjuvant chemotherapy | ||||
| Yes | N/A | .086 | .028 (0-27.4) | .31 |
| No | N/A | |||
| Concurrent chemoradiation | ||||
| Yes | 59.13 | .895 | .895 (.17-4.63) | .895 |
| No | 88.29 | |||
| Adjuvant chemotherapy | ||||
| Yes | 83.62 | .51 | 1.73 (.34-8.93) | .51 |
| No | 74.93 | |||
| Previous radiation dose | ||||
| 60 Gy or below | N/A | .20 | .031 (0-179.25) | .43 |
| Above 60 Gy | N/A | |||
| Previous IMRT | ||||
| Yes | 67.65 | .94 | .94 (.18-4.84) | .94 |
| No | 88.41 | |||
| Previous SRS | ||||
| Yes | N/A | .63 | .044 (0-9 329 347.2 | .75 |
| No | N/A | |||
| Previous proton beam therapy | ||||
| Yes | N/A | .33 | .040 (0-879.85) | .53 |
| No | N/A | |||
| Ongoing treatment for primary cancer at ORN diagnosis | ||||
| Yes | 9.1 | .005 * | 10.32 (1.41-75.57) | .022 * |
| No | 101.95 | |||
| Treatments for ORN | ||||
| Medical treatment before surgery | ||||
| Yes | N/A | .76 | .79 (.17-3.62) | .76 |
| No | N/A | |||
| Antibiotric course after ORN surgery | ||||
| Yes | 81.72 | .34 | 2.67 (.32-22.28) | .36 |
| No | 38.37 | |||
| Reconstruction type | ||||
| Local closure | 50.55 | .018 * | 5.15 (1.14-23.3) | .033 * |
| Free tissue transfer | 80.33 | |||
*P values < .05 were considered statistically significant.
COPD, chronic obstructive pulmonary disease; HR, hazard ratio; IMRT, intensity-modulated radiation therapy; ORN, osteoradionecrosis; RFS, recurrence-free survival; SRS, stereotactic radiosurgery. N/A – median values not reached.