TABLE 6.
Risk of bias assessment of randomized intervention trials examining dietary sodium and its effect on subclinical cardiovascular disease measures1
| Reference | Indicator | Effect | Intervention randomly allocated | Concealed allocation process | Participants/staff blinded to intervention | Adequate follow-up | Indicator assessors blinded to intervention | Prespecified indicator |
|---|---|---|---|---|---|---|---|---|
| Parallel RCT | ||||||||
| Colin-Ramirez et al. (31) | BNP concentration | 0 | L | U | NA | L | L | U |
| Hummel et al. (42) | BNP concentration; C-reactive protein; troponin | 0 | U | U | NA | H | L | L |
| Fabricio et al. (33) | BNP concentration; HR | 0 | L | L | L | L | L | L |
| Crossover RCT | ||||||||
| Riphagen et al. (54) | BNP concentration | + | L | L | NA | L | L | L |
| Babcock et al. (23) | Cardiovagal baroflex sensitivity; HR | + | U | U | NA | U | L | U |
| Baqar et al. (25) | Cardiac baroflex sensitivity; AIX; HR | +; 0; 0 | U | U | L | L | L | U |
| Gijsbers et al. (36) | PWV; HR; AIX | 0 | L | L | L | L | L | L |
| Muth et al. (50) | PWV | + (A); 0 (C) | U | U | NA | U | U | U |
| Suckling et al. (58) | PWV | 0 | L | L | L | L | L | L |
| Rorije et al. (55) | Microvascular density | 0 | L | L | NA | H | L | L |
| Total high rankings | 0 | 0 | 0 | 0 | 2 | 0 | 0 | |
1
n = 7. A, adults; AIX, Augmentation Index; BNP, β-type natriuretic peptide; C, children; H, high; HR, heart rate; L, low; NA, not applicable; PWV, pulse wave velocity; RCT, randomized controlled trial; U, unclear.